[Effect of hyperbaric oxygenation on the corticosterone content of the blood in experimental acute respiratory distress syndrome].

The three series of experiments conducted on 139 adult wistar rats it was found, that two-hour stay of the animals in barochamber under the pressure of 3 atmospheres reduces considerably the percentage of mortality rate and decelerates the development of arterial hypoxemia in rats with an experimental model of acute respiratory distress syndrome (ARDS) reproduced by intrapleural injection of oleic acid (0.27 ml/100 g). Stalle in comparison with the control (I) series elevation of corticosterone in the animal blood II and III series (conduction of HBO correspondingly in 4 and 12 hours from the beginning of the process) is considered as the manifestation of one of the most important mechanism of organism adaptation to the development of acute hypoxia in ARDS.

[Use of hyperbaric oxygenation to correct an acute experimental respiratory insufficiency syndrome].

The results of the experiments on 159 Wistar rats have shown that one two-hour session of hyperbaric oxygenation (HBO) under the pressure of 3 ata affects considerably the course of acute respiratory insufficiency syndrome: the mortality rate decreases markedly, the development of arterial hypoxemia and structural changes peculiar to the "wet" lung could be averted. The results of the investigations demonstrate the possibility of HBO application for the prophylaxis and treatment of the syndrome.