[Aspects of morphology of photodynamic destruction].

The results of light and electron microscopic study of the photodynamic destruction of the mouse liver with the use of Russian and imported photosensitizers (PS) at the concentration peak are presented. Considerable differences in the primary targets are noted; the changes correlated at the tissue and ultrastructural level. The use of two PS showed the damage of the soluble part of the cytoplasm: generalized cytoplasm damage with the involvement of main cell organelles in one case and the destruction of the sinusoidal lining and the hepatocyte sinusoidal pole with a diffuse spread of changes beyond the main focus of the damage close to the vascular bed in the other.

[The pharmacokinetics of fluorescein, hematoporphyrin and its derivative during the development of granuloma].

In experiments on rats with granuloma reproduced by subcutaneous implantation of foreign material there was shown a slowing of excretion from the organism as well as a considerable redistribution between the organs of fluorescein, hematoporphyrin and its derivative as compared with intact animals. The noted changes practically did not depend on the time of granuloma development.

[The pharmacokinetics of hematoporphyrin, its derivative and fluorescein during the development of carcinosarcoma].

The pharmacokinetics of fluorescein, hematoporphyrin and a derivative of hematoporphyrin was studied microspectrofluorometrically on rats with transplanted carcinosarcoma. It was shown that in the rats in contrast to intact animals the tissue concentration of fluorescein exhibits a general tendency towards an increase, that of hematoporphyrin towards a decrease and that of hematoporphyrin derivative towards an increase in all parenchymatous organs and a decrease in the skin and mucosae of the hollow organs. At the equally short period of the maximal accumulation of luminophores, the tumour tissue differs from the normal one by a pronounced delay of excretion only of hematoporphyrin derivative.

[Kinetic characteristics of 22Na transport in human and rat erythrocytes during cytoplasm acidification and cell compression].

Under normal conditions (pH0 = 7.4, pHi = 7.1-7.