Publications by authors named "G G Nicolini"
This review discusses available evidence on the mechanisms of action of bacterial lysates, and the clinical effects of their sublingual administration. Bacterial lysates act through many immunological effects, including dendritic cell activation, modification of circulating lymphocyte subsets and antibody production. The production of salivary IgA was repeatedly shown to be induced by the sublingual administration of a prototype bacterial lysate containing soluble and corpuscular antigens.
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- - The study explored how inositol (INO) supplementation affects heart changes in mice caused by lithium (Li) exposure, using four different mouse groups over a 12-week period.
- - Findings showed that INO supplementation significantly reduced heart-related issues caused by Li, such as heart function impairment and arrhythmias, possibly by restoring potassium channel expression and inhibiting certain signaling pathways.
- - INO was effective both as a preventive measure when given with Li and as a therapeutic treatment when given after heart damage had occurred, highlighting its potential as a treatment for Li-induced heart problems.
Thyroid Hormones (THs) play a central role in the development, cell growth, differentiation, and metabolic homeostasis of neurosensory systems, including the retina. The coordinated activity of various components of TH signaling, such as TH receptors (THRs) and the TH processing enzymes deiodinases 2 and 3 (DIO2, DIO3), is required for proper retinal maturation and function of the adult photoreceptors, Müller glial cells, and pigmented epithelial cells. Alterations of TH homeostasis, as observed both in frank or subclinical thyroid disorders, have been associated with sight-threatening diseases leading to irreversible vision loss i.
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