Investigation of Natural Dyes and Taxonomic Identification of Fibers Used in Chancay Textiles by Vibrational Spectroscopy and Mass Spectrometry.

Textiles provide a valuable source of information regarding past cultures and their artistic practices. Understanding ancient textiles requires identifying the raw materials used, since the origin of dyes and fibers may be from plants or animals, with the specific species used varying based on geography, trade routes and cultural significance. A selection of nine Chancay textile fragments attributed to 800-1200 CE were studied with liquid chromatography mass spectrometry (LC-MS) and direct analysis in real time mass spectrometry (DART-MS) to identify the chemical compounds in extracts of natural dyes used to create green, blue, red, yellow and black colors.

Interlaboratory and cross-platform accessibility of time-of-flight wood identification database.

The mass spectral database of tree species built by US Fish and Wildlife Service has thousands of entries and has been a valuable resource to combat illegal logging and international trade. The database was and continues to be constructed using a particular ambient ionization time-of-flight mass spectrometry (TOF-MS) platform in the agency branch in Ashland, OR, with which queries of unknown wood samples are investigated exclusively. Laboratories that operate different MS instruments also have an interest in using the database if they can produce valid matches to known samples compatible with the database.

Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector.

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) protein. This epithelial anion channel regulates the active transport of chloride and bicarbonate ions across membranes. Mutations result in reduced surface expression of CFTR channels with impaired functionality.

Selective Sampling to and Desorption from Single Solid-Phase Microextraction Arrow Fiber for Replicative and Quantitative Analysis.

New analytical functionality is demonstrated with an enclosed interface that joins a solid phase microextraction (SPME) device, a direct analysis in real time (DART) probe, and a high-resolution mass spectrometer. With a single 20 mm long SPME Arrow, the interface is able to perform five discrete DART analyses on different areas of the same fiber in 1 min of practical operation time. Three-fiber replicates for 15 runs total produce 15% or better center of variance (CV) values for both volatile headspace sampling and direct immersion sampling of a solvated analyte.

Non-proximate Sampling and Photoionization for Damage-Free Mass Spectrometric Analysis of Intact Native American Baskets.

Selected examples of Native American woven woodsplint basketry created between 1870 and 1983 are studied to recover traditional knowledge about their manufacture by identifying dyes or colorants. An ambient mass spectrometry system is designed to sample from intact objects with minimal invasiveness, neither cutting solids from the whole, exposing objects to liquid, nor leaving a mark on a surface. Baskets up to 60 cm wide in one dimension are placed on height-adjusted mounts.