Causal Effect of Smoking and Cessation on Tooth Loss.

Aim: To estimate the causal effects of smoking and cessation on tooth loss using instrumental variable (IV) analysis.

Material And Methods: Data from the Behavioural Risk Factor Surveillance System (BRFSS), conducted from 1995 to 2006, 2008, 2010, and 2012 in 50 U.S.

Effects of cannabidiol on biomineralization and inflammatory mediators expression in immortalized murine dental pulp cells and macrophages under pro-inflammatory conditions.

Objectives: This study investigated the in vitro effects of cannabidiol (CBD) on dental pulp cells and macrophages under pro-inflammatory conditions.

Materials And Methods: Mouse dental pulp cells (OD-21) were pre-stimulated with tumor necrosis factor alpha (10 ng/mL) or left untreated, then exposed to CBD at concentrations of 0.01 µM, 0.

Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry.

Background: The Covid-19 pandemic caused a negative impact on other infectious diseases control, prevention, and treatment. Consequently, low and middle-income countries suffer from other endemic diseases, such as tuberculosis. This study was designed to compare Covid-19 manifestations and outcomes between patients with previously treated tuberculosis and controls without this condition.

Seven versus 14 days of antimicrobial therapy for severe multidrug-resistant Gram-negative bacterial infections in intensive care unit patients (OPTIMISE): a randomised, open-label, non-inferiority clinical trial.

Background: Shorter courses of antimicrobial therapy have been shown to be non-inferior to longer durations for the management of several infections. However, data on critically ill patients with severe infections by multidrug-resistant Gram-negative bacteria (MDR-GNB) are scarce. In the duratiOn of theraPy in severe infecTIons by MultIdrug-reSistant gram-nEgative bacteria (OPTIMISE) trial, we assessed the non-inferiority of 7-day versus 14-day antimicrobial therapy for patients with intensive care unit (ICU)-acquired severe infections by MDR-GNB.

Big Data and Oral Health Disparities: A Critical Appraisal.

Big data has emerged as a pivotal asset in addressing oral health disparities in recent years. Big data encompasses the vast pool of health care-related biomedical information sourced from diverse channels, such as claims data, patient registries, and electronic health records (EHRs). This study is a critical review that synthesizes the evidence, identifies gaps in knowledge, and discusses future implications regarding big data analytics and oral health disparities.