[Immunological predictors of acute post-stroke period].

Introduction: At the present time, there is an increased interest in the search for biological predictors of the course and outcome of ischemic stroke (IS). Numerous studies have shown the relationship between neuroinflammation (in the brain) and systemic inflammatory response (in the blood).

Aim: To study the relationship of inflammatory and autoimmune markers in blood serum of patients with acute ischemic stroke (on the 1st day) with the dynamics of the severity of neurological deficit (on the 1st and 10th day) and to assess the predictive ability of these indicators.

[The dynamics of markers of apoptosis in the acute period of ischemic stroke].

Aim: To study the dynamics of markers of apoptosis (Bcl-2, p53) in serum in the acute period of ischemic stroke (IS) in comparison to the severity of the neurological condition and the volume of infarct.

Material And Methods: Fifty-one patients (mean age 60.5±2.

[Pathogenetic aspects of the development of acute focal cerebral ischemia].

Current concepts on the main mechanisms of brain damage in ischemic stroke are considered. Chemical regulation of physiological and pathological processes of maintaining cellular pool is supported by a multistep system that included compounds of different structure and complexity. A complex assessment and comparison of the processes taking place during the development of acute local cerebral ischemia (necrosis, apoptosis, autoimmune inflammatory reaction, neuroplasticity) can help in the objectification and prognosis of individual characteristics of the course and outcome of ischemic stroke.

[Corticosterone-induced changes in the inhibitory neurotransmission in hippocampal CA1 synapses depending on the activity of inhibitory synapses that express cannabinoid receptors].

Aim: To study an effect of corticosterone (100 nM) on spontaneous inhibitory postsynaptic currents (sIPSC) in pyramidal neurons of CA1 area and a role of inhibitory CB1-expressing synapses in the development of corticosterone-induced effects.

Material And Methods: The experiments were performed on acute slices of the rat ventral hippocampus using whole-cell configuration of the patch-clamp technique.

Results And Conclusion: The addition of corticosterone resulted in a small, but significant, increase in the frequency of sIPSCs during the first 10 minutes and then this parameter returned to the basal level.

Corticosterone Induces Rapid Increase in the Amplitude of Inhibitory Response in Hippocampal Synapses with Asynchronous GABA Release.

Experiments were performed on cultured slices of rat ventral hippocampus. Using extracellular stimulation and patch clamp recording from pyramidal neurons in the hippocampal CA1 area, we studied characteristics of GABAergic synapse formed on these neurons by cholecystokinin-expressing interneurons. This synapse was characterized by asynchronous release of GABA and depolarization-induced suppression of inhibitory response.