[An experimental study of the immunogenic and protective properties of Coxiella burnetii strain M-44 and a live enteral vaccine against Q fever].

High effectiveness of C.burnetii strain M-44 was confirmed in experimental studies on subcutaneously immunized guinea pigs ¿correction of pig] after their intratracheal infection with the virulent culture of the infective agent. The study revealed that the dose necessary for the enteral immunization of guinea pigs and monkeys was 10(4.

[The protective activity of the attenuated strain 15 of the Venezuelan equine encephalomyelitis virus in rodent infection via the respiratory tract].

Administration to rodents (Syrian hamsters, mice, guinea pigs, rabbits) of minimal doses of attenuated strain 15 VEE (up to 20 ImD50) provided protection against respiratory challenge with a highly virulent strain of Venezuelan equine encephalomyelitis virus. The protection is observed in a wide range of doses (up to LD50 hundreds and even thousands).

[The postvaccinal reaction in hamadryas baboons to the administration of attenuated strain 15 of the Venezuelan equine encephalomyelitis virus].

Immunization of Papio hamadryas with attenuated VEE virus (strain 15) causes seroconversion in 100% of animals. Postvaccinal reaction such as viremia and short-lasting fever occurs in response to the injection of 10(3) ImD50 in about 30% of animals. CNS lesion symptoms characterizing infection of Papio hamadryas with natural Trinidad strain do not occur in response to injection with attenuated strain.