Publications by authors named "G G Chabot"
Glass fragments (16 green glasses and 2 red glasses) were handpicked from crushed Trinitite. X-ray diffraction studies revealed that these samples were essentially pure glass with the exception of minor amounts (less than 4 wt%) of quartz (which acts as a diluent) in some samples. The concentrations of 45 elements in the Trinity glasses were determined using Instrumental Neutron Activation Analysis.
View Article and Find Full Text PDFBackground: Capmatinib is a selective MET inhibitor with demonstrated efficacy in a phase II study of non-small cell lung cancer (NSCLC) patients harboring METex14 mutations. However, the real-world outcomes of capmatinib are largely unknown. From June 2019, the French Early Access Program (EAP) provided capmatinib to METex14 NSCLC patients who were ineligible for or for whom first-line standard therapies had failed.
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- Pembrolizumab and nivolumab, two immunotherapy drugs, are used to treat advanced non-small cell lung cancer (NSCLC), and a recent study (IDEE) aimed to assess their safety and effectiveness in real-world conditions.
- The study included 117 patients, revealing a median age of 67 years, a 79% survival rate at 12 months, and a median time to treatment failure of 9.2 months, with 28% of failures due to toxicity.
- Overall, the findings suggest that the double-dose regimen is feasible, with no major safety or efficacy concerns identified from the real-life data.
Background: Management of stage-III-N2 non-small-cell lung cancer (NSCLC) based on a multimodal strategy (surgery or radiotherapycombined with systemic drugs) remains controversial. Patients are treated with a curative intent, and available data suggestprolonged survival after complete resection. However, no consensual definition of "tumor resectability" exists.
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- Lean patients with NAFLD can experience cardiac issues without already having metabolic problems or obesity.
- Researchers studied mice with liver mitochondrial deficiencies, which develop liver fat but not obesity, to understand this connection.
- The findings revealed that male mice showed more significant cardiac dysfunction and metabolic disturbances than female mice, who had different cardiometabolic problems involving liver and cardiac lipid imbalances.
- This research highlights how liver metabolism can lead to cardiac issues differently in males and females, emphasizing the need to explore these gender-related differences further in lean NAFLD.