The emerging clinical relevance of genomic profiling in neuroendocrine tumours.

Background: Neuroendocrine tumours (NETs) arise from hormone-producing or nervous system cells and can develop from anywhere in the body. They have heterogeneous origins from skin to gastrointestinal track and a complicated histology. Thus, there is an inevitable need for genomic profiling to determine the exact genetics of each tumour for prognosis and treatment strategies to overcome the disease's complexity.

[Rational use of antibiotics--basis for prevention of their side effects].

Three hundred and sixty eight case histories of pulmonological patients and 127 case histories of other patients were examined retrospectively. Morphohistochemical investigation of the internal ear structure was performed on rabbits treated with different aminoglycoside antibiotics in various doses. Within 15 years (from 1978 to 1992) the incidence of adverse reactions to the antibiotic therapy in the pulmonological patients decreased from 33 to 5 per cent as a result first of all of the observation of the principles of antibiotic therapy by the physicians.