[The efficacy of active specific immunotherapy using modified neoplastic cells in the combined modality treatment of hemoblastoses].

Efficiency was studied of active specific immunotherapy (IT) with cell vaccine consisting of allogenic viable cryopreserved modified Con A blast cells identical with the illness in patients with acute myeloblastic leukemia and acute lymphoblastic leukemia. The studies made confirmed a positive impact of IT on the clinical course of acute leukosis (prolonged remission, keeping down infectious complications), on leukopoiesis, peripheral blood cells enzymatic status as well as on cell immunity, certain factors of humoral immunity and bodily natural antineoplastic resistance.

[The criteria of disorders in body antitumor resistance in subjects with dyshemopoiesis].

A complex of methods is proposed adapted to practices common in clinical and diagnostic laboratories that enables the state of bodily antitumoral resistance to be properly assessed. A diagnostic system of disturbances in the antineoplastic resistance of the organism, which makes for detection of endogenous factors marking a high risk for the development of oncohemopathology is suggested.

[The cytomorphological characteristics of the hemopoietic cells in a preleukemic state].

The peripheral blood from 30 patients presenting with preleukosis states was studied. Both quantitative and qualitative indices of blood and bone marrow were determined. It has been ascertained that the following signs should be taken in consideration where the diagnosis is "preleukosis": anemia presenting with qualitative changes in erythron, neutrophylopenia presenting with a shift to the left, thrombocytopenia, nuclear anomalies of neutrophylocytes and lymphocytes (pelgeroides, fragmentation, pyknosis, Rider's nuclei).

[The criteria for forming risk groups among the population exposed to ionizing radiation after the accident at the Chernobyl Atomic Electric Power Station].

Studied were particular features of peripheral blood, certain immunological and biochemical indices under long-term exposure of human body to radiation after the accident at the Chernobyl Nuclear Power Plant. The study comprised 5578 individuals. The examinees were liquidators of the Chernobyl accident sequels (n = 1052), inhabitants of Pripyat evacuated from the town (n = 850), the Kiev SSBT primary donors (n = 1738).

[The function of the T immunity system in patients with hemoblastoses undergoing polychemotherapy].

The theophylline test was used to evaluate the state of T-system immunity in patients with different variants of acute leucosis and in mice with transplantable NK/lymphoma against the background of chemo- and immunotherapy. Analysis of cellular immunoregulatory subpopulations and comparison with the frequency and character of inverse effect of theophylline on the reaction of E-rosette formation showed high informative value and prognostic significance of the theophylline test in patients with hemoblastoses.