Beyond-classical computation in quantum simulation.

Quantum computers hold the promise of solving certain problems that lie beyond the reach of conventional computers. Establishing this capability, especially for impactful and meaningful problems, remains a central challenge. Here we show that superconducting quantum annealing processors can rapidly generate samples in close agreement with solutions of the Schrödinger equation.

Microbiological, Inflammatory and Clinical Outcome of Citric Acid Passivated Definitive Abutments: Interim 12-Month Results From a Randomised Controlled Clinical Trial.

Aim: To assess the efficacy of citric acid passivation on implant abutments by evaluating their impact on bacterial load, microbiome composition, inflammatory response, and clinical and radiographic outcomes compared with control abutments over a 12-month follow-up period.

Methods: Implants were placed subcrestally in the posterior sextants and randomly assigned to receive a 2-mm high definitive abutment, either with citric acid passivation (CA group) or without (CTR group). Final restorations were delivered after 12 weeks.

Interview Type and Signal Preferences of Interview Applicants to a Physical Medicine and Rehabilitation Residency Program: A Pilot Study.

This study examined preferences in interview type and signals among applicants interviewed by a non-surgical residency program during the 2023-2024 application cycle. A Qualtrics survey was sent to 88 interview applicants of a university-based Physical Medicine and Rehabilitation (PM&R) residency program. Main outcomes included interview type preference the applicants had with our PM&R program only and their interview type preference with multiple PM&R programs, and preferred number of signals.

Atypical Early Onset Alzheimer's Disease in a Young Female: A Case Report.

Early-onset Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the development of amyloid plaques and neurofibrillary tangles at an earlier age. It affects multiple cognitive domains, including memory, executive function, and motor abilities. Here, we present a case of atypical early-onset AD.

Looking for approved-medicines to be repositioned as anti-Trypanosoma cruzi agents. Identification of new chemotypes with good individual- or in combination-biological behaviours.

Background: The neglected illness Chagas disease is treated with limited efficacy and adverse effects by old drugs. Due to the low interest of pharmaceutical industry in targeting economically depressed-patients, repurposing is a tool that should be applied because it can introduce new anti-Chagas entities into the clinic at reduced costs.

Objectives: To investigate the repurposing/combination of medicines strategies as anti-Chagas treatment.