Publications by authors named "G Fuca"
In preclinical experiments, cyclic fasting-mimicking diets (FMDs) showed broad anticancer effects in combination with chemotherapy. Among different tumor types, triple-negative breast cancer (TNBC) is exquisitely sensitive to FMD. However, the antitumor activity and efficacy of cyclic FMD in TNBC patients remain unclear.
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- Cervical cancer still has a poor prognosis despite treatment advances, especially for patients progressing after chemotherapy and immunotherapy, where traditional options are limited.
- Antibody-drug conjugates (ADCs), like tisotumab vedotin, show promise for recurrent/metastatic cervical cancer, demonstrating improved response rates and progression-free survival in trials.
- Key unresolved issues include the optimal timing for ADC use, combination therapy strategies to combat resistance, and managing specific toxicities, with a future focus on biomarker-driven patient selection to enhance treatment effectiveness and safety.
The clinical landscape of antibody-drug conjugates in endometrial cancer.
Int J Gynecol Cancer
November 2024
Clinical outcomes remain challenging in advanced or recurrent endometrial cancer due to tumor heterogeneity and therapy resistance. Antibody-drug conjugates are a novel class of cancer therapeutics, representing a promising treatment option for endometrial cancer. Antibody-drug conjugates consist of a high-affinity antibody linked to a cytotoxic payload through a stable linker.
View Article and Find Full Text PDFBackground: Although telemedicine has been proven to have significant potential for improving care for patients with cardiac problems, there remains a substantial risk of introducing disparities linked to the use of digital technology, especially for older or socially vulnerable subgroups.
Objective: We investigated factors influencing adherence to a telemedicine-delivered health education intervention in patients with ischemia, emphasizing demographic and socioeconomic considerations.
Methods: We conducted a descriptive, observational, prospective cohort study in consecutive patients referred to our cardiology center for acute coronary syndrome, from February 2022 to January 2023.