Publications by authors named "G Frigieri"
Aim: To assess the changes of intracranial pressure waveforms (ICPW) acquired noninvasively in a set of acute hydrocephalus patients prior to and posterior to interventions.
Material And Methods: Patients with clinical and radiological diagnoses of hydrocephalus were evaluated for alterations in ICPW by means of a system that detects cranial micro expansions just before and immediately after interventions. The system quantified the difference between ICPW peaks (P1 and P2), providing the P2/P1 ratio.
Introduction: Septic shock, a life-threatening condition, can result in cerebral dysfunction and heightened mortality rates. In these patients, disturbances in cerebral hemodynamics, as reflected by impairment of myogenic cerebral autoregulation (CA), metabolic regulation, expressed by critical closing pressure (CrCP) and reductions in intracranial compliance (ICC), can adversely impact septic shock outcomes. The general recommendation is to maintain a target mean arterial pressure (MAP) of 65 mmHg but the effect of different MAP targets on cerebral hemodynamics in these patients is not clear and optimal targets might be dependent on the status of CA.
View Article and Find Full Text PDFIs the ICP pulse waveform P2/P1 ratio during -6° head-down tilt associated with relative VO peak? A non-invasive intracranial compliance monitoring approach.
Brain Spine
August 2024
Article Synopsis
- - The study investigates how spaceflights affect intracranial compliance (ICC) and the relationship between cardiorespiratory fitness and the P2/P1 ratio of intracranial pressure waveforms during microgravity conditions (simulated by a head-down tilt position).
- - Involving 34 participants who underwent cardiopulmonary exercise testing to assess their fitness levels, the study measured P2/P1 ratios using a non-invasive sensor during a 30-minute head-down tilt.
- - Results showed a negative correlation (-0.388) between cardiorespiratory fitness (measured by peak oxygen uptake) and the P2/P1 ratio, suggesting improved fitness might lead to better ICC in simulated weightlessness.
Use of intracranial compliance to assist arterial blood pressure adjustment in critical patients: Short report and review of the literature.
Surg Neurol Int
August 2024
Background: Blood pressure management is extremely important to prevent cerebral hypoxia and influence the outcome of critically ill patients. In medicine, precise instruments are essential to increase patient safety in the intensive care unit (ICU), including intracranial compliance (ICC) monitoring. A new technology developed by Brain4care, makes it possible to analyze the waveform of intracranial pressure (ICP) non-invasively associated with ICC, and this instrument was used in the patient for monitoring.
View Article and Find Full Text PDFCharacterization of intracranial compliance in healthy subjects using a noninvasive method - results from a multicenter prospective observational study.
J Clin Monit Comput
December 2024
Article Synopsis
- An FDA-approved non-invasive intracranial pressure (ICP) monitoring system was used to study variations in ICP waveforms across different age groups to assess intracranial compliance in healthy volunteers.
- The study involved 188 healthy participants aged 9 to 74, measuring the non-invasive ICP waveform, P2/P1 ratio, and time-to-peak over a 5-minute period while lying down.
- Results showed that men had lower P2/P1 ratios and time-to-peak than women, with both measures increasing with age, highlighting the need for more extensive research to establish reference values for health assessments.