Publications by authors named "G Friedman"

Article Synopsis
  • Adoptive cell therapy (ACT) with retrovirally transduced T cells and TriVax vaccination shows promise in boosting antitumor immune responses by expanding specific T cell populations.
  • Stat5, a transcription factor, is crucial for T cell proliferation and differentiation, and the study investigates engineered CD8 T cells with active STAT5 in combination with TriVax.
  • Results demonstrate that CA-STAT5 enhances T cell expansion, functional capabilities, and reduces exhaustion, leading to a stronger antitumor effect in melanoma models by inhibiting the PD-1/PD-L1 pathway.
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Article Synopsis
  • There are major gaps in understanding how immunotherapy affects the nervous system in children, mostly due to a lack of research focused on pediatric patients.
  • Identifying and grading the neurotoxic effects of immunotherapy in children is complicated by inconsistent terminology and the variation in treatment responses based on factors like disease type and therapy methods.
  • The review emphasizes the need for further research into the specific neurotoxic effects of various immunotherapy approaches in pediatric oncology, as well as the unique challenges presented by combining therapies.
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Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).

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Article Synopsis
  • Lecanemab, an amyloid-targeting immunotherapy for Alzheimer’s, shows promise but comes with potential risks for patients.
  • An interprofessional team at a medical center developed resources like patient handouts and documentation templates to aid in the infusion process of lecanemab.
  • The team plans to share these developed resources and processes with other healthcare settings to improve implementation and monitoring.
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