Phase behavior of metastable water from large-scale simulations of a quantitatively accurate model near ambient conditions: The liquid-liquid critical point.

The molecular mechanisms of water's unique anomalies are still debated upon. Experimental challenges have led to simulations suggesting a liquid-liquid (LL) phase transition, culminating in the supercooled region's LL critical point (LLCP). Computational expense, small system sizes, and the reliability of water models often limit these simulations.

A large thigh hibernoma in a 23-years-old man: Case report.

Introduction And Importance: Hibernomas are benign soft tissue tumors containing prominent brown adipocytes that resemble normal brown fat, they occur in a wide age range (from 2 to 75 years) and make up for about 1 % of all adipocytic tumors <2 % of benign fatty neoplasms. They have traditionally been regarded as benign tumors with no potential for malignancy; due to their similarity in clinical and radiographical presentation, they are often misdiagnosed as malignant tumors like liposarcomas. While these tumors are generally considered non-malignant, their distinctive characteristics and uncommon occurrence make them an intriguing subject for medical study.

Multi-Modal Latent Diffusion.

Multimodal datasets are ubiquitous in modern applications, and multimodal Variational Autoencoders are a popular family of models that aim to learn a joint representation of different modalities. However, existing approaches suffer from a coherence-quality tradeoff in which models with good generation quality lack generative coherence across modalities and vice versa. In this paper, we discuss the limitations underlying the unsatisfactory performance of existing methods in order to motivate the need for a different approach.

Small-angle X-ray scattering unveils the internal structure of lipid nanoparticles.

Lipid nanoparticles own a remarkable potential in nanomedicine, only partially disclosed. While the clinical use of liposomes and cationic lipid-nucleic acid complexes is well-established, liquid lipid nanoparticles (nanoemulsions), solid lipid nanoparticles, and nanostructured lipid carriers have even greater possibilities. However, they face obstacles in being used in clinics due to a lack of understanding about the molecular mechanisms controlling their drug loading and release, interactions with the biological environment (such as the protein corona), and shelf-life stability.