Unrelated donor HLA re-typing effort to verify prevalence of newer alleles: HLA-A*24:23, A*30:10, DRB1*08:11, DRB1*15:03, and DRB1*15:06.

The National Marrow Donor Program (NMDP) is committed to maintaining accurate human leukocyte antigen (HLA) data for each of the 11.5 million volunteer donors on the Be The Match Registry(®) . Qualitative data analysis identified five population specific alleles suspect of being incorrectly characterized.

Association of the porcine transforming growth factor beta type I receptor (TGFBR1) gene with growth and carcass traits.

Background: Growth and carcass traits are of great economic importance in livestock production. A large number of quantitative trait loci (QTL) have been identified for growth and carcass traits on porcine chromosome one (SSC1). A key positional candidate for this chromosomal region is TGFBR1 (transforming growth factor beta type I receptor).

Mapping of genes expressed in activated porcine Peyer's patch.

To determine the chromosomal locations for genes expressed in porcine Peyer's patches, polymerase chain reaction-based mapping of expressed sequence tags (ESTs) isolated from a porcine Peyer's patch-specific cDNA library was performed across a 6500-rad swine radiation hybrid panel. A total of 116 ESTs were mapped with LOD scores >6.0, and another 11 ESTs had LOD scores between 5.

Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma.

Both trimellitic anhydride (TMA), a small molecular weight chemical, and ovalbumin (OVA), a reference protein allergen, cause asthma with eosinophilia. To test the hypothesis that different allergens elicit symptoms of asthma via different effector pathways, gene expression was compared in lungs of Balb/c mice sensitized with either TMA or OVA, followed by intratracheal challenge with TMA conjugated to mouse serum albumin (TMA-MSA) or OVA, respectively. Sensitized animals challenged with mouse serum albumin (MSA) alone were controls.

Characterization and radiation hybrid mapping of expressed sequence tags from the canine brain.

Maps of the canine genome are now developing rapidly. Most of the markers on the current integrated canine radiation hybrid/genetic linkage/cytogenetic map are highly polymorphic microsatellite (type II) markers that are very useful for mapping disease loci. However, there is still an urgent need for the mapping of gene-based (type I) markers that are required for comparative mapping, as well as identifying candidate genes for disease loci that have been genetically mapped.