Publications by authors named "G Flandin"
Article Synopsis
- The Brain Imaging Data Structure (BIDS) is a community-created standard for organizing neuroscience data and metadata, helping researchers manage various modalities efficiently.
- The paper discusses the evolution of BIDS, including the guiding principles, extension mechanisms, and challenges faced during its development.
- It also highlights key lessons learned from the BIDS project, aiming to inspire and inform researchers in other fields about effective data organization practices.
Neuroimaging research requires purpose-built analysis software, which is challenging to install and may produce different results across computing environments. The community-oriented, open-source Neurodesk platform ( https://www.neurodesk.
View Article and Find Full Text PDFArticle Synopsis
- The Brain Imaging Data Structure (BIDS) is a collaborative standard designed to organize various neuroscience data and metadata.
- The paper details the history, principles, and mechanisms behind the development and expansion of BIDS, alongside the challenges it faces as it evolves.
- It also shares lessons learned from the project to help researchers in other fields apply similar successful strategies.
Neuroimaging data analysis often requires purpose-built software, which can be challenging to install and may produce different results across computing environments. Beyond being a roadblock to neuroscientists, these issues of accessibility and portability can hamper the reproducibility of neuroimaging data analysis pipelines. Here, we introduce the Neurodesk platform, which harnesses software containers to support a comprehensive and growing suite of neuroimaging software (https://www.
View Article and Find Full Text PDFBackground: Epithelial-mesenchymal-transition (EMT) is an epigenetic-based mechanism contributing to the acquired treatment resistance against receptor tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) cells harboring epidermal growth factor receptor ()-mutations. Delineating the exact epigenetic and gene-expression alterations in EMT-associated EGFR TKI-resistance (EMT-E-TKI-R) is vital for improved diagnosis and treatment of NSCLC patients.
Methods: We characterized genome-wide changes in mRNA-expression, DNA-methylation and the histone-modification H3K36me3 in -mutated NSCLC HCC827 cells in result of acquired EMT-E-TKI-R.