Publications by authors named "G Fishman"
Article Synopsis
- * Researchers identified 21 human ITPR1 GOF variants and created a mouse model with one of these variants (ITPR1-W1457G), which was found to be prone to stress-induced ventricular arrhythmias.
- * Both mouse models and human data suggest that ITPR1 GOF variants increase Ca handling abnormalities and arrhythmia risk, with 7 rare ITPR1 variants in a human database showing similar GOF behavior linked to cardiac
Article Synopsis
- Glycemic control during critical illness is crucial, with recommendations suggesting insulin therapy for glucose levels over 180 mg/dL, and possibly lowering it to 140 mg/dL for non-diabetics; this study explored the relationship between different glucose thresholds and 90-day mortality.
- A retrospective study analyzed data from 1,429 critical patients, revealing that diabetic individuals had higher mean glucose levels and mortality rates compared to non-diabetics.
- The findings indicated that non-diabetic patients with glucose levels exceeding 150 mg/dL were at a greater risk of mortality within 90 days, highlighting the importance of managing hyperglycemia in this group.
Hypophosphatemia (serum phosphate < 2.5 mg/dL) is a major concern when initiating nutritional support. We evaluated which factors contribute to hypophosphatemia development in critically ill patients, as well as the association between hypophosphatemia and mortality.
View Article and Find Full Text PDFBackground: Cancer diagnoses often begin with consultations with GPs, but the non-specific nature of symptoms can lead to delayed diagnosis. Unexpected weight loss (UWL) is a common non-specific symptom linked to undiagnosed cancer, yet guidelines for its diagnostic assessment in general practice lack consistency.
Aim: To synthesise evidence on the association between UWL and cancer diagnosis, and to review clinical guidelines and recommendations for assessing patients with UWL.