Publications by authors named "G Firneisz"
Article Synopsis
- Recent studies indicate that the TyG index and HOMA-IR may have different levels of predictive value for coronary artery calcification, despite both being indicators of insulin resistance.
- The research analyzed 39 women with specific PNPLA3 rs738409 genotypes to investigate how liver fat content influences these insulin resistance indices using various metabolic assessments.
- Findings revealed that the GG genotype, associated with a higher risk of non-alcoholic fatty liver disease, significantly disrupted the correlation between the TyG index and HOMA-IR, while both indices remained strongly correlated with hepatic triglyceride content.
Rebound increase in circulating dipeptidyl peptidase 4 (DPP4) enzyme activity after acute COVID-19.
Proc Natl Acad Sci U S A
January 2023
Background: TCF7L2 rs7903146 and PNPLA3 rs738409 gene variants confer the strongest risk for type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD), respectively. Pancreatic triacylglycerol content (PTGC) was reported to have a role in T2DM development. We aimed to assess the correlation between PTGC and hepatic triacylglycerol content (HTGC) stratified by PNPLA3 rs738409 genotype and subsequently interactions between PTGC and gene variants associated with β-cell dysfunction (TCF7L2, WFS1) and visceral adiposity (11ΒHSD1) on β-cell function were also tested.
View Article and Find Full Text PDFTo investigate the serum circulating DPP4 activity in patients with COVID-19 disease. Serum samples from 102 hospitalized COVID-19 patients and 43 post-COVID-19 plasma donors and 39 SARS-CoV-2 naive controls and their medical data were used. Circulating DPP4 activities according to different COVID-19 disease peak severity (WHO) groups at sampling and at peak were assessed.
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