A critical role of action-related functional networks in Gilles de la Tourette syndrome.

Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants.

Conditional and Unconditional Social Transfers, Early-Life Nutrition, and Child Growth: A Randomized Clinical Trial.

Importance: Rates of exclusive breastfeeding are declining despite the numerous benefits to mothers and their children.

Objective: To assess the effectiveness of conditional and unconditional social transfers on exclusive breastfeeding rates and child growth.

Design, Setting, And Participants: This is a prospective, parallel, 3-armed randomized clinical trial conducted between August 2022 and October 2023.

Hidden size: Size representations in implicitly coded objects.

Its angular representation on the retina does not solely determine the perceived size of an object. Instead, contextual information is interpreted. We investigated the levels of processing at which this interpretation occurs.

Effect of a youth-led early childhood care and education programme on children's development and learning in rural Sindh, Pakistan (LEAPS): a stepped-wedge cluster-randomised implementation trial.

Background: In low-income and middle-income countries, an estimated 181·9 million (74·6%) preschool-aged children do not receive adequate nurturing care in health, nutrition, protection, learning, and responsive care, thus jeopardising their healthy development across the life course. Working alongside the health sector, multisectoral actions including social protection and education are necessary to achieve child health and development outcomes. Innovations are needed to expand access to high-quality early childhood care and education (ECCE) for young children and opportunities for youth development.

Context-dependency of the REM sleep behavior disorder screening questionnaire - Clinical utility under scrutiny.

Introduction: The REM Sleep Behavior Disorder (RBD) Screening Questionnaire (RBDSQ) is a widely established screening tool for detecting isolated RBD (iRBD). However, its accuracy may depend on its application context, e.g.