Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial.

Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtained from tumor tissue of each individual patient to stimulate T cell responses against up to 20 neoantigens. This ongoing phase 1 study evaluated autogene cevumeran as monotherapy (n = 30) and in combination with atezolizumab (n = 183) in pretreated patients with advanced solid tumors.

Liberating the Postpartum Body: The Effects of Movement on Body Image Amongst Postpartum Ultra-Orthodox Women in Israel.

Body image is a major postpartum problem negatively correlated with postpartum depression. The present study tests this correlation amongst ultra-Orthodox women in Israel and analyses whether movement classes are effective in improving postpartum body image. Utilising a mixed-methods approach, the study followed two groups of ultra-Orthodox postpartum women (n = 45): one group that participated in movement classes (n = 23) and a comparison group that did not (n = 22).

Body, belief, and postpartum recovery: perceptions of exercise, body image, and postpartum wellbeing amongst ultra-Orthodox women.

Exercise during the postpartum period positively influences mothers' mental health, including body image, which is critical for a successful postpartum experience. Ultra-Orthodox women, subject to strict religious laws governing their bodies, strongly adhere to the commandment to procreate, resulting in a higher birth rate compared to the general population. These unique characteristics may find expression in the way religion shapes their postpartum body image and exercise experience.

Multicenter Phase 1b/2a Clinical Trial of Radioprotectant BIO 300 Oral Suspension for Patients With Non-Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy.

Purpose: Radiation therapy is part of the standard treatment regimen for non-small cell lung cancer (NSCLC). Although radiation therapy is an effective tool to manage NSCLC, it can be associated with significant dose-limiting toxicities. These toxicities can lead to treatment interruption or early termination and worsening clinical outcomes in addition to reductions in patient quality of life.

Case report: Efficacy of lutetium-177 oxodotreotide for neuroendocrine tumor with central nervous system metastases.

Neuroendocrine tumors (NETs) rarely metastasize to the brain. However, when they occur, NET brain metastases are associated with a poor prognosis. Due to their low incidence, NET brain metastases are poorly studied, with few data to guide a consensus for management.