Magnetic properties and the crystal field problem for tetragonal HoBa(2)Cu(3)O(x).

Magnetic susceptibilities of the first and third orders as well as the magnetization of the singlet paramagnet HoBa(2)Cu(3)O(x) (x≈6.0) at low temperatures are studied experimentally using a SQUID magnetometer and compared with theoretical calculations. The magnetic behaviour of single-crystal HoBa(2)Cu(3)O(x) at low temperature is found not to follow the one calculated on the basis of the known crystal field parameters.

Pasteur Euroconference on future therapies for an anxious world.

The aim of this meeting was to explore the molecular targets for tomorrow's drugs with a group of European and North American speakers from the pharmaceutical industry and academia presenting both data and ideas. Several speakers considered 5-hydroxytryptamine(1B/D) (5-HT(1B/D)) receptor antagonists to be a promising target for the treatment of obsessive compulsive disorders (OCD). 5-HT moduline, a peptide modulator of the 5-HT(1B/D) receptor, presents a potentially subtle way of intervention.

Role of GABA-ergic and serotonergic systems in the anxiolytic-like mechanism of action of a 5-HT-moduline antagonist in the mouse elevated plus maze.

5-HT-moduline is an endogenous tetrapeptide, which acts specifically as an antagonist of 5-HT1B auto- and heteroreceptors. HG1 is an ethyl arylmethyloxypiperidine acetate and an antagonist of 5-HT-moduline, which has no 5-HT-moduline agonist effect. In a pilot study, HG1 has demonstrated an anxiolytic-like profile in three mouse models of anxiety (elevated plus maze, light/dark, four plates).

High field magnetic transitions in the mixed holmium-yttrium iron garnet Ho(0.43)Y(2.57)Fe(5)O(12).

High static magnetic field magnetization measurements have been performed up to 23 T on Ho(0.43)Y(2.57)Fe(5)O(12) single crystals at helium temperature (T = 4.

Anxiolytic profile of HG1, a 5-HT-moduline antagonist, in three mouse models of anxiety.

HG1 is a new 5-HT-moduline antagonist which is itself an endogenous tetrapeptide specifically acting as an antagonist of 5-HT(1B) auto- and heteroreceptors. Blockade of endogenous 5-HT-moduline might provoke anxiolysis, so it could be a new therapeutic target in anxiety disorders. The aim of our study was to examine the effects of HG1 in three mouse models of anxiety: the four plates test (FPT), the black and white (B&W) model and the elevated plus maze (EPM).