Publications by authors named "G F de Sa"
The host immune system is adapted in a variety of ways by tumour microenvironment and growing tumour interacts to promote immune escape. One of these adaptations is manipulating the metabolic processes of cells in the tumour microenvironment. The growing tumour aggressively utilise glucose, its primary energy source available in tumour site, and produce lactate by Warburg effect.
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- Periventricular nodular heterotopia (PNH) is a brain condition caused by faulty neuron migration, leading to the formation of abnormal gray matter near the lateral ventricles, primarily affecting females due to its genetic link to the Filamin A gene on the X chromosome.
- A case study involving a 28-year-old woman with a history of respiratory issues and a family background of asthma and epilepsy showed signs of PNH in her female fetus at 20 weeks of pregnancy through ultrasounds and neurosonography.
- Genetic testing confirmed the PNH diagnosis in both the fetus and the mother, highlighting the importance of advanced imaging and genetic analysis in prenatal care for managing hereditary conditions.
An organoid culture system better recapitulates the cellular structure, function, and interaction between cells and the extracellular matrix (ECM) than a two-dimensional (2D) culture system. We here constructed a condylar cartilage organoid to explore the regulatory role of primary cilia. Similar to the natural condylar cartilage, the condylar cartilage organoid exhibited abundant ECM and comprised superficial, proliferative, and hypertrophic zones.
View Article and Find Full Text PDFObjective: To assess the diagnostic validity of ICDAS clinical criteria on 3D dental models from intraoral scanning.
Methods: This is a retrospective analysis on part of the baseline sample collected in a cohort study and included 73 participants (12-19 years) from Denmark and Greece. The assessment was made by visual inspection, and then by visual inspection associated with radiographs.
Melaleuca alternifolia essential oil in a natural product-based formulation: Antimicrobial and healing effects in Staphylococcus aureus-infected wounds.
Eur J Pharm Biopharm
September 2024
Owing to its exposed nature, the skin can be injured by various factors, including by Staphylococcus aureus, which inhabits its innate microbiota. Treatment of infected wounds presents an important challenge, making it imperative to develop new treatment options. Plant-derived formulations, such as those containing Melaleuca alternifolia essential oil (MaEO), are used for wound treatment because of their healing, anti-inflammatory, and antimicrobial properties.
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