SCREEN: A Graph-based Contrastive Learning Tool to Infer Catalytic Residues and Assess Enzyme Mutations.

Unlabelled: The accurate identification of catalytic residues contributes to our understanding of enzyme functions in biological processes and pathways. The increasing number of protein sequences necessitates computational tools for the automated prediction of catalytic residues in enzymes. Here, we introduce SCREEN, a graph neural network for the high-throughput prediction of catalytic residues via the integration of enzyme functional and structural information.

Liver transplantation for critically ill patients with acute on chronic liver failure: a prospective national programme of waitlist prioritisation.

Background: Acute on Chronic Liver Failure (ACLF) complicates chronic liver disease (CLD) combining rapidly progressive hepatic with extra-hepatic multiple organ failure and high short-term mortality. Effective therapeutic options are very limited, and liver transplantation (LT) seldom utilised through concerns of high recipient mortality and resource use. Retrospective reports suggest recent outcomes may have improved, but use of LT for ACLF has not been prospectively assessed.

Dispositional Traits, Characteristic Adaptations, and Narrative Identity Reconstructions in Individuals With Depersonalization and Derealization.

Introduction: Depersonalization and derealization disorder (DPDR) is a debilitating condition. To date, little was known about the role of personality structure and of perceived social support and loneliness in DPDR.

Methods: Three studies investigated, respectively: (i) broadband personality traits (five-factor model), maladaptive trait domains (PID-5), and perceived support and loneliness in individuals with self-reported DPDR (N = 160) versus a general population sample (N = 303), using network modeling; (ii) structure and interconnectivity of personality, perceived support and loneliness, and DPDR traits (frequency/duration) in individuals with self-reported DPDR (N = 160); (iii) characteristic adaptations and narrative identities in individuals with self-reported DPDR (N = 19), using thematic analysis.