Publications by authors named "G F Wasserman"
-chronic graft vs. host disease (cGVHD) is associated with substantial morbidity and mortality. We aimed to analyze advances in treatment strategy and outcomes during the last decade due to the incorporation of novel immunosuppressive therapy (IST) drugs in the armamentarium.
View Article and Find Full Text PDFThe quorum-sensing system links metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of HO, a crucial host defense against . We now report that protection by surprisingly extends beyond post-exponential growth to the exit from stationary phase when the system is no longer turned on. Thus, can be considered a constitutive protective factor.
View Article and Find Full Text PDFAddressing the behavioral health needs of youths involved in the justice system is key to reducing recidivism risk and preventing long-term system involvement. However, rates of treatment referral and initiation remain low, especially among minoritized youths and boys. The e-Connect System, a digital, clinical decision support system, addresses this problem by increasing rates of behavioral health treatment referral and initiation rates among youths on probation.
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- The quorum-sensing system enhances bacterial survival against the host's reactive oxygen species (ROS) by providing a protective factor that persists beyond typical metabolic stages when this system is usually active.
- Deletion of a specific gene led to increased respiration and fermentation in bacteria, but surprisingly resulted in lower ATP levels and growth due to a hyperactive metabolic state, making these mutant cells more vulnerable to oxidative damage.
- The study shows that the protective effects of quorum sensing not only help bacteria resist immune attacks but also influence the spread of infection in mice, indicating that this mechanism is likely a common defense strategy for various bacterial species.