Publications by authors named "G F Smirnova"
N-Glycoside of Indolo[2,3-]pyrrolo[3,4-]carbazole LCS1269 Exerts Anti-Glioblastoma Effects by G2 Cell Cycle Arrest and CDK1 Activity Modulation: Molecular Docking Studies, Biological Investigations, and ADMET Prediction.
Pharmaceuticals (Basel)
December 2024
Indolo[2,3-]pyrrolo[3,4-]carbazole scaffold is successfully used as an efficient structural motif for the design and development of different antitumor agents. In this study, we investigated the anti-glioblastoma therapeutic potential of glycosylated indolocarbazole analog LCS1269 utilizing in vitro, in vivo, and in silico approaches. Cell viability was estimated by an MTT assay.
View Article and Find Full Text PDFEndogenous HS has been proposed to be a universal defense mechanism against different antibiotics. Here, we studied the role of HS transiently generated during ciprofloxacin (CF) treatment in M9 minimal medium with sulfate or produced by E. coli when fed with cystine.
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- Extracts from certain fodder grasses have been shown to inhibit growth and biofilm formation in avian pathogenic strains, both individually and alongside antibiotics.
- The research found that the extracts could enhance the effectiveness of multiple antibiotics against both biofilms and free-floating bacteria, including antibiotic-resistant strains.
- The extracts exhibited low prooxidant activity, which might change how certain biological processes work, leading to stronger effects when used with antibiotics.
Article Synopsis
- In Gram-negative bacteria, stress-induced growth arrest leads to the release of hydrogen sulfide, which comes from the breakdown of intracellular cysteine to prevent toxic accumulation.
- Research using electrochemical sensors showed that both Gram-positive and Gram-negative bacteria produce sulfide during growth arrests caused by low nutrients or antibiotics, with notable changes in physiological parameters.
- Differences in sulfide production between the two types of bacteria are attributed to the absence of glutathione in Gram-positive bacteria, suggesting that this process may represent a previously unknown natural source of hydrogen sulfide.
We investigated antimicrobial and antioxidant activity of nitrogen-containing heterocycles and their acyclic analogues, some of which can be considered as promising in terms of biological activity. Based on structure, 26 tested compounds were divided into 4 groups. In the test with 2,2-diphenyl-1-picrylhydrazyl (DPPH), the compounds of the group 2 had the highest radical-binding activity (RBA) (53-78%), while those of group 3 had the lowest values (1.
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