Publications by authors named "G F Peters"
This study investigates the intricate dynamics underlying lipase performance in organic solvents using comprehensive molecular dynamics (MD) simulations, supported by enzyme kinetics data. The study reveals that a single criterion can neither predict nor explain lipase activity in organic solvents, indicating the need for a comprehensive approach. Three lipases were included in this study: lipase B (CALB), lipase (RML), and lipase (TLL).
View Article and Find Full Text PDFBackground: While just-in-time (JIT) training is associated with time and cost savings, limited evidence directly compares layperson CPR performance using JIT videos to in-person CPR courses. We measured layperson CPR performance using a JIT video compared to an in-person course or no training.
Methods: Adult employees at a professional sports stadium were randomized to perform CPR in a simulated scenario a) after completing an AHA HeartSaver® course, b) using a JIT training video, or c) neither (control).
Background: Guidelines recommend using high-sensitivity troponin T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) to risk stratify hemodynamically stable patients with acute pulmonary embolism (PE). However, there are no evidence-based cutoff values defined for this clinical application.
Methods: We performed a single-center, retrospective cohort study of patients with imaging-confirmed PE and hsTnT and/or NT-proBNP (ElecsysTM, Roche) measured 12 h before or 24 h after PE Response Team (PERT) activation.
Objectives: Gestational diabetes is diagnosed using an oral glucose tolerance test (OGTT), which has limited accuracy, reproducibility and practicality. We assessed the effect of enhanced pre-analytical glucose processing upon glucose concentrations, gestational diabetes diagnosis, health equity and pregnancy outcomes, and if HbA1c was a suitable alternative.
Methods: We recruited pregnant women with ≥1 risk factor to a prospective observational cohort study of pregnancy hyperglycaemia, endocrine causes, lipids, insulin and autoimmunity (OPHELIA), from nine UK centres.
Article Synopsis
- 5-Fluorouracil (5-FU) is a primary treatment for colorectal cancer and is often combined with leucovorin (LV) to enhance its effectiveness by targeting thymidylate synthase (TS).
- The study compared Arfolitixorin (Arfo), an active form of folate, to LV in combination with 5-FU in patients with colorectal cancer liver metastases to see which produces better TS inhibition and folate levels.
- Results showed that Arfo led to significantly higher levels of folate (MeTHF) and increased TS inhibition compared to LV, indicating that Arfo may be a more effective option, though the difference in TS inhibition wasn't statistically significant.