Guidance on the production of EuGMS guidelines.

The European Geriatric Medicine Society (EuGMS) will publish clinical guidelines grounded in evidence-based knowledge pertaining to identification, prevention, diagnosis and management of conditions that are relevant to older people. The primary goal is to produce relevant recommendations that address areas not currently covered by organ-based clinical guidelines, thereby mitigating uncertainty and enhancing the quality of care for older patients, in particular those with multimorbidity and frailty. This document, approved by the Academic Board and the Executive Board of the EuGMS, informs on the creation and organization of the Guideline Committee, the procedures to develop clinical guidelines, methodological aspects and ethical issues related to their production and dissemination.

Clinical management of three JMML siblings with germline CBL variation.

Germline pathogenic variants (PVs) in CBL are found in 15 % of juvenile myelomonocytic leukemia (JMML) cases. Here we report three siblings with CBL(NM_005188):c.1111T>C variation presenting a heterogenous JMML clinic and outcome.

Evaluating the utilisation patterns of pharmacological therapy in COVID-19 patients: an ecological study in Italy.

Backgound: The drug central monitoring system set up in Italy to evaluate the real-time trends of medicines used in hospital and primary care settings contributed to inform drug supplies, avoided stockpiling and allowed to monitor adherence to clinical practice guidelines for the treatment of COVID-19 patients. The primary objective of the study is to understand how and to what extent the drug utilisation tracked the evolution of COVID-19 pandemic and evaluate the different pharmacological approaches adopted in hospital and primary care settings.

Methods: A national ecological study correlating the drug utilisation of specific categories of drugs related to SARS-CoV-2 with the number of SARS-CoV-2 hospitalised or positive subjects.

Adolescents with Persistent Symptoms Following Acute SARS-CoV-2 Infection (Long-COVID): Symptom Profile, Clustering and Follow-Up Symptom Evaluation.

Background: Few studies have evaluated long-COVID in adolescents.

Methods: Cohort study. Demographics, clinical data, and the presence of 30 symptoms were collected with a modified WHO form.

The impact of age, sex, and gender on polypharmacy and potential prescribing cascades: Lessons from five databases.

Background: Few studies describe how gender-related factors may contribute to polypharmacy and prescribing cascades. Describing these patterns using cross-national comparisons can improve the robustness of findings and provide lessons on the importance of considering age, sex, and gender in pharmacological research. The aim of the study was to explore the intersection of age, sex, and gender with polypharmacy and co-prescribing suggesting a potential prescribing cascade.