Publications by authors named "G F Musso"
Purpose: Previous studies show that transgender and gender-diverse (TGD) individuals, especially those assigned male at birth (AMAB), often have low bone mineral density (BMD) before beginning gender-affirming hormone therapy (GAHT). The reasons for this are not fully understood, and the potential role of androgen receptor (AR) polymorphisms - known to affect bone density in the general population - has not been explored. This study aims to assess the impact of AR polymorphisms on bone health in the TGD population.
View Article and Find Full Text PDFBackground: Penile dynamic color doppler duplex ultrasound (CDDU) is a relevant tool in assessing men with suspected vasculogenic erectile dysfunction (V-ED).
Aim: To investigate (1) factors potentially associated with V-ED to define risk classes useful in predicting V-ED; (2) the response to phosphodiesterase type 5 inhibitors (PDE5i); and (3) the onset of incident major cardiovascular (CV) events.
Methods: A cohort of men with ED and without known concomitant CVD was grouped into: patients undergoing CDDU (N.
We investigate the role of homeostatic mechanisms involved in acute, postprandial nutrient metabolism and nutrient-induced systemic inflammation in CKD presence and progression in Metabolic dysfunction-associated steatohepatitis (MASH). We assessed postprandial incretins (GLP-1 and GIP), intestinotropic hormone GLP-2, endotoxin LPS, Zonulin (a marker of intestinal permeability), hepatokines, adipokines and NF-kB activation in circulating MNCs during a meal tolerance test in 52 biopsy proven MASH patients randomized to curcumin Meriva or placebo and 26 matched controls. At baseline, MASH-CKD had a lower GLP-2 response and a 2-fold higher postprandial LPS and NF-kB activation in MNCs than MASH patients without CKD, but similar remaining postprandial or fasting parameters.
View Article and Find Full Text PDFExploring the effect of patient characteristics on the association between warm ischemia time and the risk of postoperative acute kidney injury after partial nephrectomy.
Urol Oncol
November 2024
Article Synopsis
- - This study examines how warm ischemia time (WIT) influences the relationship between pre-existing health conditions and kidney function after partial nephrectomy in patients with renal cell carcinoma.
- - Researchers analyzed data from 802 patients who underwent surgery, finding that those with higher comorbidity risks were more likely to face acute kidney injury (AKI) and long-term chronic kidney disease (CKD) after surgery.
- - The results showed that while WIT had a minimal effect on AKI risk for low-risk patients, it significantly impacted high-risk patients, indicating the need for careful preoperative discussions for patients with multiple health issues.
Article Synopsis
- Salivary alpha-amylase (sAA) has been proposed as a better biomarker for stress, surpassing cortisol due to fewer measurement limitations and variability factors like age and collection methods.
- The study involved collecting saliva samples from healthy subjects and obstetric residents at various times, assessing sAA levels before and after a stressful simulation, including heart rate monitoring.
- Results showed significant increases in sAA post-stress scenario and from morning to afternoon, indicating sAA's reliability for measuring stress responses, with potential implications for stress-related disorders.