[Structural and cytochemical changes in cerebral cortical neurons of the offspring of neurosensitized female rats after prenatal administration of thymalin].

Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation. Course treatment with the drug prevented the development of dystrophic changes in cortical neurons, their death and decrease in cell density within the cortical layers. Timalin acted positive in terms of increase in protein content of the cellular nucleus and especially in the cytoplasm.

[Effect of the neurosensitization of female rats on the functional indices of the DNA-, RNA- and protein-synthesizing neuronal apparatus of the cerebral cortex and of the immune system in their progeny].

Neurosensitization effects on the state of the ribonucleoprotein particles and chromatin in nuclei of the Vth layer cortical neurons were studied in female rats. Anti-brain antibodies were investigated in their offspring on the 30th and 60th days. On the 60th day the electron-cytochemical changes were found in the nuclei suggesting the deterioration of nucleolar DNA processing and inhibition of nucleolar functional activity.

[Histological and cytochemical changes in the cerebral cortex of the progeny of alcohol-administered animals].

The authors examined the sensomotor cortex of the brain of 30- and 60-day-old progeny of non-inbred female rats alcoholized for 4 months prior to and during pregnancy. The offspring presented structural and cytochemical signs of the malformation of the cerebral cortex and dystrophic changes. Signs characteristic of neuro-ontogenetic impairment include: retardation in the growth of the cortical width, the size of neurons, accumulation in them of protein substances and insufficient variability of classes of neurons in respect of protein concentrations.

[Electron microscopic and cytointerferometric study of the cortical neurons from the 2d-generation progeny of preneurosensitized female rats].

A study was made of the sensorimotor cortex of the brain of the second generation offspring of preneurosensitized female rats. Vacuolization of the neurocyte nuclei, elevated lability of nuclear membranes, appearance of numerous dark neurons were discovered at all times of postnatal ontogenesis (from 2 to 90 days). At the same time ultrastructure of a considerable number of neurons was unchanged.