In Vitro Analysis of Enamel Abrasion Using a Novel Manual Nano-Bristle Toothbrush: An Atomic Force Microscopy Study.

Introduction: To evaluate the enamel abrasion effects of soft, ultra-soft, and nano-bristle toothbrushes using atomic force microscopy (AFM) to guide toothbrush selection for optimal enamel preservation.

Methods: This in vitro study involved 45 extracted human teeth (central and lateral incisors), randomly assigned to three groups (n=15 each): Group I (nano-bristle), Group II (ultra-soft bristle), and Group III (soft bristle). Each specimen underwent 10,000 brushing cycles with a standardized 2 N force to simulate one year of brushing.

Investigation of ritonavir analogs antiretroviral natural compounds against SARS-CoV-2 envelope protein.

Since the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported from Wuhan, China, there has been a surge in scientific research to find a permanent cure for the disease. The main challenge in effective drug discovery is the continuously mutating nature of the SARS-CoV-2 virus. Thus, we have used the I-TASSER modeling to predict the structure of the SARS-CoV-2 viral envelope protein followed by combinatorial computational assessment to predict its putative potential small molecule inhibitors.

Evaluation of the Antimicrobial Efficacy of Ethanolic and Aqueous Extracts of Licorice (Glycyrrhiza glabra) Against a Periodontal Pathogen: An In Vitro Study.

Background: Periodontal disease is a major contributing factor to tooth loss and can significantly impact overall health. Traditional periodontal therapy typically involves mechanical debridement to remove plaque and calculus, along with the use of antimicrobial agents to reduce bacterial load. Licorice () has a long history of use in traditional medicine for treating various ailments since it contains glycyrrhizin, glabridin, liquiritin, and flavonoids, which possess anti-inflammatory, antioxidant, and antimicrobial activities.

Evaluation of the Effect of Aegle marmelos (Bael Leaf) Extract on Human Fibroblast Viability: An In Vitro Study.

Aim To evaluate the biocompatibility of ethanolic extract of (bael/vilvam) leaves with gingival fibroblast cells.  Materials and methods Commercially available bael leaves were used to produce a herbal ethanolic extract using the cold percolation technique. Evaluation of cytotoxicity of the bael leaf extract (BLE) on fibroblast cell line at six different concentrations (200µl/ml, 100µl/ml, 50µl/ml, 25µl/ml, 12.