Publications by authors named "G F Ibikunle"
Background: This study was designed to determine the hepatoprotective effect of partially purified fractions from extract on carbon tetrachloride (CCl) intoxicated rats.
Methods: The methanol extract of was subjected to solvent partitioning using n-hexane, chloroform, ethylacetate and water. Separation of fractions with proven antioxidant activity was achieved by chromatographic techniques.
Antiplasmodial and analgesic effects of crude ethanol extract of Piper guineense was investigated in mice. The antiplasmodial and analgesic efficacy of the extract was judged on its ability to reduce parasitemia and writhing, respectively, in mice. The antiplasmodial screening involved treating infected mice with 200, 400, and 600 mg/kg body weight of extract while the positive control group was given standard artesunate drug.
View Article and Find Full Text PDFEugenia uniflora, used ethnomedically in some tropical countries as an anti-infective, has shown anti-malarial and anti-trypanocidal activities. Therefore using bioactivity guided fractionation, anti-trichomonal activity of E. uniflora leaf was investigated.
View Article and Find Full Text PDFArticle Synopsis
- Clausena lansium, also known as Fool's Curry Leaf, is traditionally used for treating conditions like bronchitis, malaria, and gastrointestinal inflammation, and serves as a substitute for the Curry leaf tree.
- The study assessed the medicinal properties of the plant's stem bark, focusing on its effects against inflammation, liver toxicity, diabetes, and a specific parasite (Trichomonas gallinae).
- Results indicated that the dichloromethane extract was more effective against Trichomonas, and the methanolic extract significantly improved insulin levels, demonstrating potential anti-diabetic properties primarily through stimulating insulin release.