Publications by authors named "G F Faust-Tinnefeldt"

Article Synopsis
  • The study analyzed the influence of HLA-DRB1 and -DQB1 alleles on disease progression in 201 rheumatoid arthritis (RA) patients, identifying a significant association with the HLA class II alleles sharing the (Q)R/KRAA amino acid motif.
  • Among RA patients, 79% had the (Q)R/KRAA motif, with homozygosity significantly linked to increased severity of rheumatoid factor positivity and disease outcomes measured by Larsen Score and Health Assessment Questionnaire.
  • However, the genetic predisposition indicated by HLA-DR did not correlate with severe extraarticular disease, suggesting that while HLA-DR is important for RA susceptibility, it may have limited utility in predicting individual disease progression.
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The cervical spine is the second most common location for manifestation of rheumatoid arthritis (RA). Symptoms are typically related to involvement of the craniocervical junction. Unfortunately, conventional radiographic examination is often unable to demonstrate that RA is the cause of such symptoms.

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In vitro stimulation with influenza-A antigens of the peripheral lymphocytes from patients with rheumatoid arthritis is significantly higher than that in those from healthy controls. Stimulation was performed without autologous serum, is dependent on the monocyte function and correlates with disease activity. Gold compounds can inhibit monocyte function and so the lymphocyte stimulation by influenza-A antigens.

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Patients with rheumatoid arthritis show increased levels of anti-influenza-A antibodies in their sera compared to healthy controls and patients with other inflammatory rheumatic diseases (systemic lupus erythematosus, ankylosing spondylitis and psoriatic arthritis). These antibody levels are dependent on the activity of rheumatoid arthritis.

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The influence of maintenance therapy with Isoxicam, 200 mg daily, on digoxin steady-state plasma levels was studied on 12 healthy volunteers. One person dropped out from the investigation program on account of cardiac sensations following the invasion phase with digoxin. No statistically significant differences could be shown during concomitant therapy or after withdrawal of Isoxicam.

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