[Structural and molecular origin of information recording/reading].

On the basis of experimental data on the thermoinduced state of water dispersions of natural and synthetic phospholipids in the presence of nootropic agents, a new phenomenological molecular mechanism of information recording/reading was proposed. The mechanism is based on the polymorphism of membrane lipids. A new approach, to the problem of memory was suggested, which considers memory as an information data bank and separates this concept from the concept of the mechanisms of information recording/reading.

[Mechanism of polymorphic transformations in phosphatidylcholine membranes].

Based on the 31P NMR, PMR, and EPR data on the thermally induced behavior of water dispersions of natural and synthetic phospholipids in the presence of membranotropic agents: the neuropeptide adrenocorticotropic hormone and beta-(4-oxy,3,5-ditretbutyl-phenylpropionic acid), a new mechanism of the interaction of membranotropic substances with the molecules of hydrate shells of membrane phospholipids was proposed, which underlies polymorphic transitions in phosphatidylcholine membranes.

[Effect of the antioxidant phenozan and neuropeptide adrenocorticotropic hormone on the structure of the liquid crystalline state of the lipid bilayer and thickness of the phosphatidylcholine membrane].

By the methods of NMR, PMR and EPR spectrometry and X-ray diffaction, the occurrence of polymorphic liquid-crystalline transformations in phosphatidylcholine liposomes from the bovine brain and the influence of phenozan (sterically screened phenol antioxidant) and adrenocorticotropic hormone were shown in the temperature range 25-55 degrees C. Phenozan and the adrenocortcotropic hormone, which have a nootropic activity in vivo, change the phase transition temperatures, promote polymorphic transformations in lipids and increase the disordering of lipid bilayer and the thickness of phosphatidylcholine membranes. We assume that the lipid polymorphysm is a step of information recording and keeping processes in synapse membranes.

[The effect of difenin, valproate and phenobarbital on the development of an epileptiform seizure attack in Krushinskiĭ-Molodkina rats].

The anticonvulsant action of diphenin, sodium valproate, and pentobarbital was studied in Krushinskiĭ-Molodkina (KM) rats subjected to audiogenic seizures. The anticonvulsant effects of the drugs were different and dose-dependent. Valproate in a dose of 120 mg/kg completely eliminated the tonic phase of seizures.