Publications by authors named "G Emri"
Unlabelled: Prognostic studies can provide important information about disease biology and improve the use of biomarkers to optimize treatment decisions.
Methods: A total of 199 patients with advanced melanoma treated with BRAF + MEK inhibitors were included in our single-center retrospective study. We analyzed the risk of progression and death using multivariate Cox proportional hazard models.
Article Synopsis
- The study investigates the impact of high-dose vitamin D supplementation on melanoma relapse in patients who have had curatively resected cutaneous melanoma (CM).* -
- A total of 436 patients were randomly assigned to either a vitamin D treatment group, receiving 100,000 IU monthly, or a placebo group, with follow-up lasting up to 116 months.* -
- Results showed that while vitamin D supplementation significantly increased serum levels, it did not noticeably improve relapse-free survival or reduce melanoma-related deaths compared to the placebo group.*
The aim of this study was to apply a state-of-the-art quantitative lipidomic profiling platform to uncover lipid alterations predictive of melanoma progression. Our study included 151 melanoma patients; of these, 83 were without metastasis and 68 with metastases. Plasma samples were analyzed using a targeted Lipidyzer™ platform, covering 13 lipid classes and over 1100 lipid species.
View Article and Find Full Text PDFEffect of education on sun-safe behaviour in kidney transplant recipients.
Photodermatol Photoimmunol Photomed
May 2024
Background: Organ transplant recipients (OTR) are more likely to develop skin cancer than the general population. One of the main components of the exposome that triggers the development of skin tumours is solar ultraviolet (UV) radiation. To reduce the incidence of harmful consequences of sun exposure, sun protection education is needed for patients taking long-term immunosuppressive drugs.
View Article and Find Full Text PDFArticle Synopsis
- Decreased expression of vitamin D receptors (VDR) in melanoma and melanocytic naevi compared to normal skin is observed, revealing a potential link to melanoma characteristics.
- A study involving 407 melanoma patients analyzed how VDR expression correlated with vitamin D levels, demographic factors, VDR genetic variants, and tumor pathology.
- Findings showed higher cytoplasmic VDR expression in patients with greater sun exposure and different genetic variants, while lower nuclear VDR expression was associated with tumor characteristics like mitosis and perineural invasion.