Glycine transporter-1 expression in the rat model of cortical dysplasia.

Objective: Glycine transporter-1 (GLYT1) is an early marker of neural development and involved in the excitatory transmission in cortex. The study was designed to investigate the expression of GLYT1 in different parts of the brain by immunohistochemistry in the rat cortical dysplasia model.

Methods: On postnatal day 0, one freeze lesion was carried out on ten rats between bregma and lambda on the skull in the right hemisphere for 5 seconds.

AgNOR values are not helpful in the differential diagnosis of pituitary adenomas.

Nucleolar organizer regions (NOR) are chromosomal segments in which ribosomal RNA is encoded. AgNOR technique, which reveals these regions, has rarely been used in the diagnosis and preceding the prognosis of pituitary adenoma. The purpose of this study was to determine and evaluate the correlation of hormonal profile with AgNOR counts, the correlation of recurrence with AgNOR counts, and to determine the consistency between the evaluations of the two independent observers.

Expression of NM23 and tenascin in invasive ductal carcinomas of the breast.

Objective: In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression.

Material And Methods: In this study 27 ductal carcinomas of the breast were analysed for expression of tenascin and nm23 antimetastasis genes by immunohistochemistry.

Results: The results of our study revealed a statistically significant correlation between nm23-H1 immunoexpression and lymph node metastasis.

Prevalence of human papillomavirus (HPV) DNA in larynx and lung carcinomas.

In this retrospective study, we investigated the HPV DNA occurrence in 21 laryngeal and 26 primary lung squamous cell carcinomas. Nonisotopic in situ hybridization (NISH) technique was performed with commercially available digoxigenin-labelled DNA probes for HPV screening. Subtyping for HPV subtypes 6/11, 16/18 and 31/33 was also performed.

Antimetastasis gene expression and numerical chromosomal abnormalities of chromosomes 1 & 17 in serous tumours of the ovary.

Objective(s): The aim of this study was to examine the expression of the antimetastasis gene nm23 and numerical changes on chromosome 1 and 17 in ovarian tumours.

Methods: In this study 20 serous cystadenocarcinomas, ten borderline and five benign tumours were analysed for expression of the nm23 antimetastasis gene by immunohistochemistry and for numerical chromosomal abnormalities of chromosomes 1 and 17 by interphase cytogenetics.

Results: Strong intracytoplasmic immunoreactivity with the antimetastasis gene was observed in late stage carcinomas but not in benign or borderline tumours or in lymph node metastases.