Publications by authors named "G Eibl"
One of the deadliest types of cancer is pancreatic ductal adenocarcinoma (PDAC). Chronic stress and obesity are recognized as risk factors for PDAC. We hypothesized that the combination of stress and obesity strongly promotes pancreatic cancer development and growth.
View Article and Find Full Text PDFDiet-induced obesity (DIO) promotes pancreatic ductal adenocarcinoma (PDAC) in mice expressing KRasG12D in the pancreas (KC mice), but the precise mechanisms remain unclear. Here, we performed multiplex quantitative proteomic and phosphoproteomic analysis by liquid chromatography-tandem mass spectrometry and further bioinformatic and spatial analysis of pancreas tissues from control-fed versus DIO KC mice after 3, 6, and 9 months. Normal pancreatic parenchyma and associated proteins were steadily eliminated and the novel proteins, phosphoproteins, and signaling pathways associated with PDAC tumorigenesis increased until 6 months, when most males exhibited cancer, but females did not.
View Article and Find Full Text PDFArticle Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer, and researchers explored using existing FDA-approved drugs like metformin and simvastatin as potential preventive measures in high-risk groups.
- In an experiment with KC mice (which are predisposed to PDAC) on a high-fat diet, the combination of low-dose metformin and simvastatin reduced weight gain and inhibited the progression of advanced cancer precursor lesions.
- The study found that this dual treatment not only slows down PDAC development but also affects key cellular pathways, suggesting metformin and simvastatin could be effective in future clinical trials for pancreatic cancer prevention.
Article Synopsis
- The study investigates the impact of statins on inflammatory macrophages and their role in the early development of pancreatic cancer, specifically looking at how statins might inhibit acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN).
- Results show that lipophilic statins reduce inflammatory cytokine production in macrophages and block ADM formation in pancreatic acinar cells.
- In vivo experiments demonstrated that simvastatin treatment led to fewer macrophages and lower inflammation-related changes in mouse pancreatic tissues, suggesting that statins may help prevent early pancreatic ductal adenocarcinoma (PDAC) development.
Background: Body mass index (BMI) during adulthood has been associated with pancreatic ductal adenocarcinoma (PDAC), however, patterns of body size across the adult life course have not been studied extensively. We comprehensively evaluated the association between adiposity across adulthood and PDAC.
Methods: We conducted a prospective analysis of 269 480 (162 735 males, 106 745 females) National Institutes of Health-AARP Diet and Health Study participants, aged 50-71 years (1995-1996) who self-reported height and weight history.