Publications by authors named "G EINAUDI"
Casein kinase II (CK2) has recently emerged as a pivotal mediator in the propagation of inflammation across various diseases. Nevertheless, its role in the pathogenesis of sepsis remains unexplored. Here, we investigated the involvement of CK2 in sepsis progression and the potential beneficial effects of silmitasertib, a selective and potent CK2α inhibitor, currently under clinical trials for COVID-19 and cancer.
View Article and Find Full Text PDFAdvanced glycation end products (AGEs) exert a key pathogenic role in the development of obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the microalga (spirulina, SP) is proposed as a nutritional supplement. Here, we investigated the potential anti-glycating properties of SP enriched with zinc (Zn-SP) and the following impact on diet-induced metabolic derangements.
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- BTK is a special protein that helps control inflammation in certain immune cells called macrophages, and it also seems to affect how fat-related immune cells work, especially in people with obesity and diabetes.
- When researchers blocked BTK in mice, it helped them stay healthier on a high-fat diet by improving how their bodies process sugar.
- This means that targeting BTK could be a new way to help reduce inflammation and treat problems related to being overweight, making it an important discovery for health.
Recurrent Binge Eating (BE) episodes characterize several eating disorders. Here, we attempted to reassemble a condition closer to BE disorder, and we analyzed whether recurrent episodes might evoke molecular alterations in the hypothalamus of rats. The hypothalamus is a brain region which is sensitive to stress and relevant in motivated behaviors, such as food intake.
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- ICOS is a protein that helps T cells, which are part of our immune system, to work better, and it has a special partner called ICOSL, found on other immune cells.
- Scientists tested a new drug called ICOS-Fc, which can either block or boost this protein relationship to help fight infections like sepsis.
- In experiments with mice, giving ICOS-Fc helped reduce symptoms and damage caused by sepsis compared to untreated mice, showing its potential as a treatment.