Publications by authors named "G E van der Kraaij"
Article Synopsis
- The study investigates how combining methotrexate with adalimumab treatment affects drug concentration and response in psoriasis patients.
- A population PK-PD model was created from data collected over 49 weeks from 59 patients, revealing that methotrexate cotreatment reduces the development of antidrug antibodies, which can enhance the effectiveness of adalimumab.
- Overall, the findings suggest that using methotrexate alongside adalimumab can lead to better treatment outcomes by increasing adalimumab levels and potentially improving clinical responses.
Article Synopsis
- Anti-drug antibodies (ADA) can form in patients treated with adalimumab (ADL), potentially reducing its effectiveness; using methotrexate (MTX) alongside ADL seems to lower ADA levels and improve outcomes in rheumatologic diseases.
- A study was conducted in the Netherlands and Belgium to compare the long-term effectiveness and safety of ADL combined with MTX versus ADL alone over three years in patients with moderate to severe plaque psoriasis.
- Results showed no significant difference in drug survival between the two groups, even though the ADL + MTX group had a trend towards longer survival; however, adverse events led to common discontinuation in the combination group.
[A man with a rare disfiguring cutaneous manifestation of sarcoidosis].
Ned Tijdschr Geneeskd
July 2022
A 42-year-old man with no relevant medical history presented with a painless, red, disfiguring skin lesion located on the nose. He was diagnosed with lupus pernio, a rare, cutaneous subtype of sarcoidosis which is relatively resistant to therapy and is associated with systemic sarcoidosis.
View Article and Find Full Text PDFImportance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.
Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.