Publications by authors named "G E Voloudakis"
Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics, the cellular specificity of these mechanisms remains largely unexplored. This study presents a comprehensive single-nucleus multi-ancestry atlas of genetic regulation of gene expression in the human prefrontal cortex, comprising 5.
View Article and Find Full Text PDFThe complex roles of myeloid cells, including microglia and perivascular macrophages, are central to the neurobiology of Alzheimer's disease (AD), yet they remain incompletely understood. Here, we profiled 832,505 human myeloid cells from the prefrontal cortex of 1,607 unique donors covering the human lifespan and varying degrees of AD neuropathology. We delineated 13 transcriptionally distinct myeloid subtypes organized into 6 subclasses and identified AD-associated adaptive changes in myeloid cells over aging and disease progression.
View Article and Find Full Text PDFPolygenic scores (PGS) enable the exploration of pleiotropic effects and genomic dissection of complex traits. Here, in 421,889 individuals with European ancestry from the Million Veteran Program and UK Biobank, we examine how PGS of 17 neuropsychiatric traits are related to membership in 22 broad professional categories. Overall, we find statistically significant but weak (the highest odds ratio is 1.
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- * By analyzing data from the Million Veteran Program and other cohorts, the study identifies 63 genetic loci linked to AMD, including 30 that were previously unknown, highlighting significant differences in risk among various ancestries.
- * The findings reveal that certain genetic risk factors, like those found in the CFH locus, have varying effects based on ancestry, suggesting that targeted therapies could be developed by considering these genetic differences.
Article Synopsis
- Parkinson's Disease (PD) is a serious brain disorder affecting over 1% of people over 60, leading to issues with movement and thinking, but its exact causes are still unclear.
- To investigate the complexity of PD, researchers conducted single-nucleus RNA sequencing and whole-genome sequencing on 100 postmortem samples, selecting cases that represent varying stages and symptoms of the disease.
- The resulting dataset, created with high standards of quality control, is freely available on the AMP PD Knowledge Platform, facilitating research into the molecular mechanisms of PD and potentially helping to improve treatment options.