Publications by authors named "G E Velasquez"
The Phase 3 randomized controlled trial, TBTC Study 31/ACTG A5349 (NCT02410772) demonstrated that a 4-month rifapentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. The primary efficacy outcome was 12-month tuberculosis disease free survival, while the primary safety outcome was the proportion of grade 3 or higher adverse events during the treatment period. We conducted an analysis of demographic, clinical, microbiologic, radiographic, and pharmacokinetic data and identified risk factors for unfavorable outcomes and adverse events.
View Article and Find Full Text PDFUnlabelled: Radiology may better define tuberculosis (TB) severity and guide duration of treatment. We aimed to systematically study baseline chest X-rays (CXR) and their association with TB treatment outcome using real-world data. We used logistic regression to associate TB treatment outcomes with CXR findings, including percent of lung involved in disease (PLI), cavitation, and Timika score, alone or in combination with other clinical characteristics, stratifying by drug resistance status and HIV (n = 2,809).
View Article and Find Full Text PDFArticle Synopsis
- Lung cancer is the leading cause of cancer-related deaths globally, but recent advancements in treatment are linked to discoveries from Next Generation Sequencing, particularly the identification of mutations like RBM10.
- A study of 50 patients with NSCLC and RBM10 mutations showed that those with the mutation had a median progression-free survival (PFS) of 6.7 months, significantly lower than the 13.9 months observed in those without the mutation.
- RBM10 mutations were linked to aggressive disease; however, the presence of concurrent mutations such as ZFHX3 and EGFR was associated with a more stable disease state, while mutations like KRAS and TP53 indicated a more aggressive progression.
Article Synopsis
- Delays in drug hypersensitivity reactions can lead to serious health issues, and the role of different T cell types in these reactions needs to be better understood.* -
- Research used advanced methods to compare skin-resident memory T cells (TRMs) and other T cell subsets in severe conditions like Stevens-Johnson syndrome (SJS) and drug reactions with eosinophilia (DRESS), versus milder conditions like morbilliform drug eruption (MDE).* -
- Results showed that TRMs play a significant role in skin-limited diseases, while SJS/TEN and DRESS involved more recruitment of cytotoxic CD8+ T cells, highlighting different immune responses and suggesting new directions for treatment and understanding of