Stimulation of jejunal mucosal protein synthesis by luminal glucose. Effects with luminal and vascular leucine in fed and fasted rats.

This study was conducted to determine whether short-term (1.75 h) luminal glucose perfusion increases the mucosal protein synthesis rate in rat small intestine. A luminal perfusate containing 56 mM glucose was compared with a control perfusate containing mannitol in two jejunal segments constructed in the same animal.

Stimulation of ammonia production from glutamine by intraluminal glucose in small intestine of dogs.

Previous studies have shown that the quantity of ammonia derived from the small intestinal metabolism of arterial glutamine was equal to ammonia released by the colon. Little is known, however, about processes that may alter small intestinal glutamine metabolism. The purpose of this study was to evaluate the effect of intraluminal, nonnitrogenous compounds on ammonia release into mesenteric venous blood and glutamine uptake from arterial blood by in situ intestinal segments in anesthetized, fasted dogs.

Effects of insulin and glucagon on the uptake of amino acids from arterial blood by canine ileum.

Insulin and glucagon have variable effects in altering arteriovenous differences for amino acids and glucose in liver and muscle. It has not been determined whether these hormones may similarly affect intestine. Acute effects of intraarterial insulin and glucagon were evaluated in in situ, luminally cleansed ileal segments in anesthetized, fasted dogs.