Publications by authors named "G E Testoni"
Glycogen is a glucose-storage polysaccharide molecule present in animals, fungi and bacteria. The enzyme glycogenin can self-glycosylate, forming an oligosaccharide chain that primes glycogen synthesis. This priming role of glycogenin was first believed to be essential for glycogen synthesis, but glycogen was then found in the skeletal muscle, heart, liver and brain of glycogenin-knockout mice (Gyg KO), thereby showing that glycogen can be synthesized without glycogenin.
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- The study focuses on the properties of Al-doped TiO thin films, known as TiO/AlO nanolaminates, created using plasma-enhanced atomic layer deposition (PEALD) on silicon and glass substrates.
- It highlights the differences in chemical phases, noting that crystalline films have excess oxygen, while amorphous films do not, along with a diagram illustrating this oxygen distribution.
- The research shows how changing the film's structure from crystalline to amorphous affects surface hardness and optical properties, which is significant for enhancing performance in various technologies like biosensors and solar cells.
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- Glycogen storage disease type IV (GSD IV) is caused by mutations in the GBE1 gene, resulting in abnormal glycogen accumulation primarily in the liver.
- Investigating Gbe1 knockout mice showed that their liver mitochondria had higher complex I respiratory activity and increased production of reactive oxygen species, especially from complex III.
- These findings suggest that GSD IV impacts overall energy metabolism and its underlying causes may involve more than just physical damage from glycogen buildup.
Background: Due to the COVID-19 pandemic, it is more essential than ever to implement protective measures in primary care centers to ensure patients' safety. This protocol describes a quasiexperimental study on the use of a mobile chat platform as a clinical consultation tool for adolescents and primary health care physicians.
Objective: The purpose of the quasiexperimental study is to demonstrate that the use of mobile phones and messaging apps increases the number of health consultations.
The glycogenin knockout mouse is a model of Glycogen Storage Disease type XV. These animals show high perinatal mortality (90%) due to respiratory failure. The lungs of glycogenin-deficient embryos and P0 mice have a lower glycogen content than that of wild-type counterparts.
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