Publications by authors named "G E Santyr"
Article Synopsis
- MBW Xe-MRI measures gas washout and ventilation in pediatric cystic fibrosis (CF) patients and its effectiveness in monitoring changes after initiating therapy with elexacaftor/tezacaftor/ivacaftor (ETI) has been evaluated.
- 12 participants underwent MBW Xe-MRI and pulmonary function tests at baseline and one month after starting ETI therapy, showing significant improvements in ventilation metrics.
- Findings indicated that MBW Xe-MRI-derived measures like fractional ventilation and coefficient of variation can effectively assess lung function changes, making it a useful tool alongside traditional pulmonary function tests in pediatric CF care.
Article Synopsis
- The study aimed to compare a new MRI technique (3D UTE PREFUL) for measuring lung ventilation to existing methods (Xe-MRI and 2D multi-slice PREFUL MRI) in children with cystic fibrosis.
- Twelve pediatric CF patients underwent various MRI scans to create regional ventilation maps, and multiple statistical methods were used to compare the ventilation defect percentages (VDP) derived from these scans.
- Results indicated that the 3D UTE PREFUL MRI correlated well with the other methods in measuring global lung VDP, suggesting it could be a more sensitive and accessible option for assessing lung ventilation in pediatric CF patients.
Background: MRI with xenon-129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi-site study.
View Article and Find Full Text PDFBackground: Primary ciliary dyskinesia (PCD) is a rare multisystem genetic disease caused by dysfunctional motile cilia. Despite PCD being the second most common inherited airway disease after cystic fibrosis, PCD continues to be under-recognised globally owing to nonspecific clinical features and the lack of a gold standard diagnostic test. Commonly repeated prevalence estimates range from one in 10 000 to one in 20 000, based on regional epidemiological studies with known limitations.
View Article and Find Full Text PDFRationale And Objectives: Emergent evidence in several respiratory diseases supports translational potential for Phase-Resolved Functional Lung (PREFUL) MRI to spatially quantify ventilation but its feasibility and physiological relevance have not been demonstrated in patients with asthma. This study compares PREFUL-derived ventilation defect percent (VDP) in severe asthma patients to healthy controls and measures its responsiveness to bronchodilator therapy and relation to established measures of airways disease.
Materials And Methods: Forty-one adults with severe asthma and seven healthy controls performed same-day free-breathing H MRI, Xe MRI, spirometry, and oscillometry.