[Matrix metalloproteinases, their inhibitors and angiogenesis in different morphological types of lung precancer in persons who have long lived in the radioactive substance-polluted area of the Semipalatinsk Region, Kazakhstan].

The aim of the present investigation was to study a role of matrix metalloproteinases and their inhibitors in the pathogenesis of fibrosis and angiogenesis in lung precancer processes, which could be used to develop new pathogenetically substantiated lines in therapy. The investigation was conducted using intraoperative and biopsy specimens of the removed lungs and their parts from 113 patients with lung precancer changes with the diagnoses of lung cancer, chronic abscess, bronchoectatic disease, idiopathic fibrosing alveolitis, tuberculosis, of whom 41 patients had lived from childhood to 2002 in vicinity of a polygon and long exposed to radiation (annual radiation dose was greater than 0.1 Rem) (Group 1).

[Immunohistochemistry of matrix metalloproteinases in different morphologic types of the lung cancer developed in the inhabitants of the Semipalatinsk Region].

The immunohistochemical characteristics of matrix metalloproteinases and their association with angiogenesis in different histological types of the lung cancer developed in the inhabitants of the Semipalatinsk Region (Kazakhstan) were investigated. The surgical and biopsy specimens from 87 patients with lung cancer, including 33 patients who had lived near the Semipalatinsk polygon from childhood to 2002 year and had been long exposed to radiation (annual radiation dose had been more than 0.1 Rem), were examined.

[Role of matrix metalloproteinases in the pathogenesis and morphogenesis of fibrocavernous tuberculosis in persons long living in the Semipalatinsk region of Kazakhstan].

The archives of surgical material (removed lungs and their parts) and autopsies of 54 patients with fibrocavernous tuberculosis (FCT) who had lived from childhood to 2003 near polluted area and exposed to radiation (the annual radiation dose was higher than 0.1 Rem) were studied. The surgical and autoptic materials from 21 patients with tuberculosis (including 6 patients lived in the Kazakhstan radiation areas and 15 patients lived in Moscow) were used as a control.

[Morphological, cytogenetic and molecular biological characteristics of lung cancer in persons exposed for a long time to radionuclide radiation pollution in the Semipalatinsk region of Kazakhstan].

Surgical and biopsy material was used from 57 patients with lung carcinoma (LC): 17 patients (group I) lived close to testing area from the childhood to 1993 and were exposed to radiation at the year dose 0.1 ber. For comparison surgical and biopsy material from 40 patients (group 2) was taken who lived in the territories of Kazakhstan (10 patients) and Moscow (30 patients) with normal radiation background.