Publications by authors named "G E Pluhar"
Article Synopsis
- Canine high-grade glioma (HGG) is a severe form of cancer that's hard to treat, largely due to differences in tumor cell types and how tumors adapt after treatment, especially in breeds like French bulldogs.
- Immunotherapy shows promise in extending survival rates but has led to poor outcomes specifically in French bulldogs, prompting research into genetic differences in their tumors compared to other breeds like boxers and Boston terriers.
- Through RNA sequencing, the study found that French bulldog tumors exhibit unique gene expression patterns and show significant changes in immune-related pathways after treatment, contributing valuable insights for developing targeted therapies for different dog breeds and potential links to human glioblastoma.
Article Synopsis
- Glioblastomas are aggressive brain tumors that are hard to treat effectively, and myeloid cells contribute to their treatment resistance through immunosuppression.
- Current therapies typically involve a 6-week radiation plan, but a quicker 3-week approach might benefit older patients or those in poor health.
- This study found that patients undergoing traditional radiation experienced higher levels of monocytes and lower levels of lymphocytes compared to those receiving a shorter radiation schedule, highlighting the need to consider blood cell changes when choosing treatment plans.
High-grade glioma is an aggressive cancer that occurs naturally in pet dogs. Canine high-grade glioma (cHGG) is treated with radiation, chemotherapy or surgery, but has no curative treatment. Within the past eight years, there have been advances in our imaging and histopathology standards as well as genetic charactereization of cHGG.
View Article and Find Full Text PDFRhabdoid meningioma is a rare type of meningeal neoplasm in humans. This study reports the clinical, pathological, and ultrastructural features of 4 cases of canine meningioma with rhabdoid features. The cases were female and 8 to 12 years of age.
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