Publications by authors named "G E Lindgren"
The global spread of Oriental Horses in the past 1,500 years through the lens of the Y chromosome.
Proc Natl Acad Sci U S A
December 2024
Article Synopsis
- Horses have been shaped by human needs through selective breeding, leading to a very uniform male-specific portion of the Y chromosome (MSY) across modern breeds.
- The study analyzed 1,517 males from 189 horse breeds, revealing the significant influence of Oriental stallions, especially Arabian and English Thoroughbred, over the past few centuries.
- Additionally, the research uncovered two major historical waves of horse dissemination, including the "Spanish influence" from the Iberian Peninsula and the spread during the Ottoman Empire's expansion, highlighting the complex ancestry of modern horses.
The Greying with age phenotype in horses involves loss of hair pigmentation whereas skin pigmentation is not reduced, and a predisposition to melanoma. The causal mutation was initially reported as a duplication of a 4.6 kb intronic sequence in Syntaxin 17.
View Article and Find Full Text PDFBackground: The Icelandic horse and Exmoor pony are ancient, native breeds, adapted to harsh environmental conditions and they have both undergone severe historic bottlenecks. However, in modern days, the selection pressures on these breeds differ substantially. The aim of this study was to assess genetic diversity in both breeds through expected (H) and observed heterozygosity (H) and effective population size (Ne).
View Article and Find Full Text PDFEffect of an endothelial regulatory module on plasma proteomics in exercising horses.
Comp Biochem Physiol Part D Genomics Proteomics
December 2024
Article Synopsis
- - The study investigates how a specific genomic regulatory module affects blood pressure and protein changes in elite racehorses during exercise, focusing on two different haplotype groups: sub-elite performing (SPH) and elite performing (EPH).
- - Researchers sampled plasma from 12 Coldblooded trotters and conducted analyses to identify differences in protein abundance related to exercise and haplotypes, discovering significant variations in plasma protein content during exercise.
- - Findings indicate that the EPH group shows a faster switch to lipoprotein and lipid metabolism during exercise, enhancing understanding of how blood pressure regulation impacts exercise performance.