Publications by authors named "G E Lash"
Article Synopsis
- Breast cancer patients show elevated serum levels of reactive oxygen species (ROS), which may impact their endometrial health, but the specific influence of tumor-derived ROS on endometrial function remains uncertain.
- A study involving both breast cancer patients and a mouse model revealed that endometrial thickness was reduced in tumor-bearing subjects, indicating potential damage caused by cancer-related factors.
- Vitamin C demonstrated a protective effect on the endometrium by reducing oxidative stress and fibrosis, suggesting it could be a therapeutic option for preserving fertility in younger women diagnosed with breast cancer.
Role of Cancer Side Population Stem Cells in Ovarian Cancer Angiogenesis.
Med Princ Pract
October 2024
Ovarian cancer is one of the most common gynecologic malignancies. Recurrence and metastasis often occur after treatment, and it has the highest mortality rate of all gynecological tumors. Cancer stem cells (CSCs) are a small population of cells with the ability of self-renewal, multidirectional differentiation, and infinite proliferation.
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- Abnormal death of granulosa cells (GCs) due to cyclophosphamide (CTX) can lead to primary ovarian insufficiency (POI), and this study explores the mechanisms involved.
- Gene analysis revealed that the ferroptosis pathway is significant, with changes in key proteins such as heme oxygenase 1 (HO-1) and glutathione peroxidase-4 (GPX4) affecting cell survival.
- Findings suggest that iron overload and reactive oxygen species (ROS) contribute to mitochondrial dysfunction, leading to ferroptosis in GCs, indicating that targeting HO-1 could help mitigate ovarian damage in POI patients.
Introduction: Interleukin-1 beta (IL-1β) can promote cell migration, invasion and metastasis in various cancer cells. The mechanism of its role in human trophoblast has not been fully investigated. Therefore, we aimed to investigate the expression level of IL-1β in first trimester decidua and placenta and its potential role in regulation of extravillous trophoblast cell (EVT) invasion and migration.
View Article and Find Full Text PDFIntroduction: Spontaneous miscarriage is a common complication of early pregnancy. Previous studies have shown that mitochondrial function plays an important role in establishment of a successful pregnancy. Cytochrome c oxidase subunit 4 isoform 1 (COX4I1), a component of electron transport chain complex Ⅳ, is required for coupling the rate of ATP production to energetic requirements.
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