Publications by authors named "G E Knox"
Article Synopsis
- Identifying new adjuvants to make vaccines more effective is crucial, with one promising method being the use of TLR9 agonists like CpG ODNs to boost dendritic cell function.
- D-15800, a specific D-peptide isomer, has been found to better stimulate the production of the immune response mediator IL-12p70 and promote differentiation of monocytes into dendritic cells compared to its L-isomer counterpart.
- When combined with TLR9 agonists, D-15800 not only activates immune cells like CD4 T and natural killer cells but also enhances interferon-alpha production, indicating it could significantly improve vaccine outcomes.
Selective Deuteration and Tritiation of Pharmaceutically Relevant Sulfoximines.
Angew Chem Int Ed Engl
October 2024
Pharmaceutical-aligned research endeavors continue to diversify, including via the installation of new chemical functionality and non-classical bioisosteres within drug design. With this, an equally high demand emerges for the direct installation of isotopic substituents into these scaffolds within drug discovery programmes, as isotopologues are essential for the elucidation of the biological efficacy and metabolic fate of the active pharmaceutical ingredient (API). The sulfoximine functional group has recently become established as a high-value unit in this context; however, general and effective methods for the synthesis of deuterium (H, D) and tritium (H, T) labelled analogues have remained elusive.
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- Breeding initiatives have focused on creating sterile cultivars of heavenly bamboo (Nandina domestica) to control its invasive growth, with various cultivars evaluated for landscape performance and seed viability across three Florida locations.
- 'Emerald Sea' and several other cultivars (like 'Greray' and 'Murasaki') showed strong visual quality ratings at all sites, but low fruit production was noted in others, like 'Chime' and 'Twilight,' which consistently failed to produce fruit.
- Seed viability was highly variable among cultivars, with low fruiting varieties like 'Murasaki' and 'SEIKA' showing only 33.3% to 66.7% viability, while 'Emer
The emergence of lethal coronaviruses follows a periodic pattern which suggests a recurring cycle of outbreaks. It remains uncertain as to when the next lethal coronavirus will emerge, though its eventual emergence appears to be inevitable. New mutations in evolving SARS-CoV-2 variants have provided resistance to current antiviral drugs, monoclonal antibodies, and vaccines, reducing their therapeutic efficacy.
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- Immune checkpoint inhibitor therapy (ICI) can worsen autoimmune diseases, but a new lipidic peptide, IK14004, shows promise in promoting immunosuppressive T regulatory cells while activating CD8+ T cells.
- IK14004 effectively inhibits Lewis lung cancer growth and revitalizes exhausted CD4+ T cells, along with modulating immune responses in human cells.
- This peptide could help balance the benefits of ICI immunotherapy by minimizing autoimmune reactions without allowing tumors to escape immune detection.