A psychological model of predictive factors of distress following long COVID.

Background: Long COVID, described as "the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection", is estimated to affect at least 10-20 % of all cases of acute SARS-CoV-2 infection. Because of its novelty, information regarding the experience of Long COVID is still emerging.

Methods: This study examines psychological distress in two long COVID populations, and their experience of fatigue, cognitive failures, experiential avoidance, rumination, and perceived injustice.

Separate and combined blockades of α- and β-adrenergic receptors in forearm sweating induced by adrenergic agents and exercise in the heat in young adults.

The assessment of adrenergic modulation of sweating as assessed via pharmacologic administration of α- and β-adrenergic receptor blockers during exercise has yielded mixed findings. However, the underlying mechanisms for this disparity remains unresolved. We investigated the effects of separate and combined blockade of α- and β-adrenergic receptors on forearm sweating induced by a 30-min moderate-intensity exercise bout (n=17, protocol 1) and the administration of adrenergic agonists epinephrine and norepinephrine (n=16, protocol 2) in the heat.

A Content Analysis of Web-Based Heat Stress Materials Published by Occupational Health and Safety Ministries, Associations, and Agencies in Canada.

An ever-increasing number of workplaces are becoming heat-exposed due to rising temperature extremes. However, a comprehensive review of Canadian safety materials available to support workplaces in managing this critical hazard has not previously been conducted. We undertook a review and a content analysis of heat stress materials on safety-based ministry, association, and agency websites in Canada (n = 155) to identify content related to heat stress (n = 595).

The effect of high-intensity exercise in temperate and hot ambient conditions on autophagy and the cellular stress response in young and older females.

The process of autophagy is vital in maintaining normal cellular function, especially during exposure to elevated states of physiological stress associated with exercise and hot ambient temperatures. Although prior observations are primarily limited to responses in males, the autophagic response to acute physiological stress in females represents a considerable knowledge gap. Therefore, we assessed autophagy and related pathways of cellular stress in peripheral blood mononuclear cells (PBMCs) from 20 healthy young [ = 10, mean (SD): aged 23 yr (3)] and older [ = 10, aged 69 yr (3)] females in response to 30 min of semi-recumbent high-intensity cycling exercise (70% of predetermined maximal oxygen consumption) in temperate (25°C) and hot (40°C) ambient conditions (15% relative humidity).

The Effect of 7-Day Cold Water Acclimation on Autophagic and Apoptotic Responses in Young Males.

While cold acclimation can enhance thermoregulation in humans, the potential to improve cellular cold tolerance remains unknown. Thus, this work aims to evaluate the effect of a 7-day cold-water acclimation on the cytoprotective mechanism of autophagy in young males. Further, this work assesses changes in cellular cold tolerance by employing hypothermic ex vivo (whole blood) cooling prior to and following acclimation.